This article is forms part of a special issue on "research on prevention and control of emerging infectious diseases" https://www.sciencedirect.com/journal/biosafety-and-health/vol/4/issue/4.
This study uncovers the evolutionary dynamics of SARS-CoV-2 and epidemiological characteristics of COVID-19 at the primary stage of massive vaccination.
Although stringent non-pharmacological interventions and massive vaccination were implemented, the pandemic continues. Vaccination breakthrough infection and reinfection in convalescent COVID-19 cases were reported. Further, SARS-CoV-2 variants emerged and exhibited a trend of immune escape. The question that if the vaccination drives genetic or antigenic drifts of SARS-CoV-2 remains elusive.
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Vaccination coverage was negatively related to the infections, severe cases, and deaths of COVID-19, respectively, at the primary stage of massive vaccination. Additionally, with the increasing vaccination coverage, the lineage diversity of SARS-CoV-2 dampened, but the rapid mutation rates (i.e. genetic drift) of the S gene were identified. The vaccination could be one of the explanations for lowering the genetic diversity but driving genetic drift in the S gene of SARS-CoV-2. The resurged new epidemics in several countries (e.g., USA and UK) with high vaccination coverage, questioned their pandemic control strategies and highlighted the cruciality of integrated vaccination and non-pharmacological interventions.
This study suggests massive vaccination could be one of the explanations for driving SARS-CoV-2 evolution and lowering its genetic diversity. This study suggests integrated vaccination and non-pharmacological interventions and a highly effective vaccine design to curb disease severity and infection possibility.
Jing Yang, Min Han, Liang Wang, Likui Wang, Tianrui Xu, Linhuan Wu, Juncai Ma, Gary Wong, Wenjun Liu, George F. Gao, Yuhai Bi, Relatively rapid evolution rates of SARS-CoV-2 spike gene at the primary stage of massive vaccination, Biosafety and Health, Volume 4, Issue 4, 2022, Pages 228-233, ISSN 2590-0536, https://doi.org/10.1016/j.bsheal.2022.07.001.
Posted in: Medical Research News | Disease/Infection News
Tags: covid-19, Evolution, Gene, Genetic, Infectious Diseases, Mutation, Pandemic, Research, SARS, SARS-CoV-2, Vaccine, Viral Disease
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